So individuals that … And this is one phenotype that I’ve been looking at, is people that have hypermobility, even mild hypermobility, and trying to source out who in my client population has that going on and can I find any links to that hypermobility and any of the symptoms and conditions that they may be dealing with. The University of British Columbia. extracellular matrix. The animal extracellular matrix includes the interstitial matrix and the basement membrane. I have observed, in other people with hyper-mobility, that there’s indications to me of low copper, either low serum or plasma copper, or low VEGF, or I’ve seen how taking supplemental copper in higher amounts can actually have a benefit to the regulation of some of these functions, that are often outward. The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local invasion to drive metastasis. But as a result of that Chinese medicine evolved to the United States and it was basically post-Maoist. Michael McEvoy: Well, so for example, there’s a number of different so-called genetic diseases which involve collagen deficiency of various kinds. Google Classroom Facebook Twitter. But the other thing is in western scientific terms most people can’t really explain what acupuncture is doing. Individuals may suffer from postural orthostatic tachycardia. In chronic illness especially you see this phenotype a lot, you see a lot of these same kinds of conditions: mast cell disorder, you see POTS. Well we think of the mitochondria as only producing ATP, but we now know that that’s only a partial truth. The extracellular matrix and cell wall. So a lot of us hear about mast cell activation disorder, mast cell activation syndrome, of which there is just chronic histamine intolerance, and then histamine intolerance eventually became MCAS – in a very short period of time now people are calling it MCAS, it’s no longer histamine intolerance. You might be wondering ”what the heck is the extracellular matrix and why should I care about it?” The Extracellular matrix is a supportive network comprised of connective tissue, collagen fibers, the lymphatic vessels, and all of the tributaries in the lymphatic system that creates the environment between and around your cells. Michael McEvoy: There was a Pissinger quote in there and the Pissinger quote, I’ll just paraphrase that. I’ve seen practitioners who are Chinese acupuncturists and Japanese acupuncturists and they both kind of will tell you that what they’re doing is superior to what the other person was doing. Log in. This is referred to often as haploinsufficiency when a gene product is so mutated from genetic defect that the functional enzyme doesn’t get made sufficiently. And so when you have matrix dysregulation, when you have mast cell activation disorder you have some type of matrix involvement that’s going on. And some researchers even speculate that it’s one of the core problems in neurodegenerative diseases especially in some like autism, but that’s other doctors inside of this talking about that kind of stuff. The thing that we need to really address, I think, is the toxicity factor, because a lot of people that are having matrix dysregulation are probably very prone and susceptible to different environmental. The consequence of this is that when the matrix becomes compromised we start to see many of the characteristic symptoms of this. ؼ�74�s(qDQ�Ѭ�m�Yh�����BΔk�e!�r��Y��Lѣ�@������ ���[���^5�_k�����&�m�L�� !ؐ5��. And furthermore, these people that we see with complex illness, they have multiple symptoms across multiple system atropy going on. So, I know that we had in mind to cover some of Heinrich Kramer’s work as well, and there was a few other topics we wanted to cover, but we’ve already gone over like an hour and a half, and I want to be sensitive to your time here. Everything's an Argument with 2016 MLA Update University Andrea A Lunsford, University John J Ruszkiewicz. Collagen makes cartilage tough, whereas the water-filled proteoglycans make it smooth and resilient. They may have CAH, congenital adrenal hyperplasia. Extracellular Matrix Jamie A Davies,University of Edinburgh, Edinburgh, Scotland, UK The extracellular matrix is the component of tissue that lies immediately outside and between cells in animals and plants. Ari Whitten: Fascinating. When the matrix becomes compromised … Well, let’s look at some basic conditions and disease processes that definitely involve degradation to the extracellular matrix. %���� And consequently if the matrix is being compromised our immune system is going to become overreactive and the function of our cells is going to be impaired in many different ways. So I think that a lot of the research that has been done in acupuncture, first of all it’s looking at using certain acupuncture points from the traditional Chinese system which we’re actually more or less … That’s like the post-Maoist acupuncture that came post 1972 when the Nixon administration went to China and they witnessed the open heart surgery using needles and a local anesthetic with the chest cavity wide open and how the hell is that possible. And they have a dual function. ECM proteins typically include multiple, independently folded domains whose sequences and arrangement are highly conserved. Different concentration gradients are going to have an effect on the matrix. Ari Whitten: I’m glad you brought this up, there’s a couple of things here. In addition to its structural role as an adhesive fiber for cell attachment, TasA acted as a developmental signal stimulating a subset of biofilm cells to revert to a motile phenotype. And this is something that’s really not a common thing for people to talk about in the health realm. So we see this is happening a lot in many different conditions. And the quote says, “Western physiology has the habit of reducing the function of the cell to an incomprehensible maze of cellular biology. Mass cell stuff is really difficult to treat effectively, but it can correct by, you know, by using certain therapies. The alpha chain has cation binding sites. We could sue different ways to stimulate the lymphatic system: jumping on a trampoline, doing exercise, sauna therapy, to mobilize the lymphatic system; muscular contraction to do that. Michael McEvoy: So glycine is probably the simplest most used amino acid in the human body and it’s integral in our DNA synthesis processes. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Remember that the matrix, it’s everywhere, it’s pervasive, it’s ubiquitously found in every organ and tissue of the body. Individuals that have joint hyperlaxity or joint hypermobility, which is very common, had at least some degree of extracellular matrix dysfunction. We know that the ATP are integral in this damage-associated molecular pattern signaling and cell danger response. We can have more detailed discussions about what some of those theories are, but in actuality they all share one common theme: it’s extracellular matrix dysfunction. A meeting place, a battleground, as well as a protective barrier, as a communicative epicenter where the immune system, the nervous system, and the endocrine systems all converge and meet to basically create a homeostatic balanced environment. What are some of the other big factors that damage matrix functioning and what are some of the big factors that people can maybe think about implementing to benefit the health of their extracellular matrix? 3 Page(s). And that bio-rhythm is going to change. We know that near infrared light attracts water to the connective tissue. We know that environmental toxins can play a tremendous role in matrix dysregulation because of the fact that the glycosaminoglycans – and forgive me for keeping just brambling on – but the glycosaminoglycans which are one of the major constituents of the extracellular matrix, they’re often referred to as GAGs. Ari Whitten: Beautiful. Extracellular Matrix. This void is filled with a complex meshwork called the extracellular matrix. And the deeper that I go into researching the extracellular matrix the more I realize that so much has been lost and so much is yet to be discovered. Extracellular matrix (ECM) is an extensive molecule network composed of three major components: protein, glycosaminoglycan, and glycoconjugate. Helpful? I was told incidentally by a doctor who is the head of two integrative medicine clinics in California that 70 to 80% of his patients are hypermobile, and he only deals with the sickest of the sick. © Copyright 2020 Ari Whitten Inc., All Rights Reserved. We’d love to hear from you! The extracellular matrix is a mixture of protein and carbohydrate components providing structural and biochemical support to cells. Then you have Marfan syndrome which is very similar. The dermal extracellular matrix (ECM) undergoes age-related remodelling which leads to wrinkle formation and increased tissue fragility. Very common symptoms in EDS and in individuals that think they have or might have EDS include some of the stuff that I’ve already mentioned such as the tissue hypoxia, extremely weak extremities or extremely weak muscle tone, muscle function, motor function has been reduced. The mechanism for repairing damaged tissue is dependent on the extracelluar matrix. I do find that that has benefit, that light therapy can correct matrix dysregulation. And that is the opening statement of this really profound book called Matrix and Matrix Regulation by Alfred Pissinger. mesothelium), or muscle cells, adipocytes, etc. But maybe we’ll have to do a part two of this podcast, and I’d love to have you on again. It’s the transport system as well as a battleground for the immune system. Medbullets Team 0 % Topic. In the case of bone a calcified glycoprotein matrix, known as osteoid matrix is the extracellular component. Michael McEvoy: Well, I mean it’s kind of absurd in a sense, and I’ll just comment on that. They also play a role in mutual recognition of similar cell types. So, what does that mean to your health and wellbeing? And so all of this research is basically pointing to a highly conserved, ancient evolutionary process that is built into the symbiotic cells – which I’m referring [inaudible] cells and [inaudible] – these highly conserved evolutionary processes that are integral in the protection against perceived threat. Abstract. CBD has been very useful to me, especially with these people that have this phenotype of matrix dysregulation. So the ATP gets ejected out of the cell into the extracellular or pericellular extracellular environment, leading to a number of additional processes including the recruitment of the innate immune system. Decellularized extracellular matrix (ECM)-based scaffolds are rapidly expanding in regenerative medicine. Nerve -- elongated process that receive, generate, and transmit nerve pulses. The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. Medicine will never evolve. Study Resources. It provides Structural support and 2. Components of the extracellular matrix The extracellular matrix presents as two clearly identifiable structures: 1, the basement membrane: a condensed matrix layer formed adjacent to epithelial cells, and other covering cell sheets (e.g. It is not just for the physical support of the cells, but also is integral to the function and behavior of the cells in many different important ways. Connective tissue - Tissues, the major constituent of which is extracellular matrix. I mean, you know, the thing with clinical hypotheses is that you’re not going to be right 100%. Yet, the extracellular environment plays a vital governing and inseparable role in the function of the cell.”. Si-Tayeb K. Lemaigre F.P. And, you know, high levels of C-reactive protein. Those positively charged metals are probably binding to, you know, the negatively charged groups just as we suspect, you know. 0. Why medical professionals in the US only focus on what is going on inside the cells rather than the extracellular matrix, What diseases are caused by a dysfunctional extracellular environment, How glyphosate affect the connective tissues, How the extracellular matrix is connected with the Cell Danger Response, How to strengthen the extracellular matrix, The most beneficial therapies for optimizing the extracellular matrix, The Extracellular Matrix — A Secret Key to Health and Energy with Michael McEvoy – Show Notes. “The Energy Blueprint”® is a trademark used by Ari Whitten Inc. By entering your email address you are also requesting and agreeing to subscribe to our email newsletter. It doesn’t necessarily only involve people with hypermobility however because … And just to that point, I’ll say that because hypermobility involves defects in collagen synthesis or decorin synthesis or different things that should be integral to the function of the matrix, because that’s happening at least to some extent it’s something that I’m looking at. Ari Whitten: Yeah. Both of these ligands mentioned above are recognized by multiple integrins. Fluid mosaic model: cell membranes article. It involves usually a complex dysregulation, a multi-system atrophy, a comorbidity, its comorbidity meaning multi-symptom, multi-disease, multi-everything going on. You know, there’s other things that seem to show up too, like the orthostatic tachycardia’s difficult. ECM components, as well as cell adhesion receptors, interact with each other forming a complex network into which cells reside in all tissues and organs. I would argue that the organ system is everything that’s around the interstitium. And that is something that Pissinger demonstrated repeatedly in the 1960s, ’70s, and probably up [inaudible] ’80s and ’90s, is that the matrix is in itself an entire organism or an entire organ system that is in a communication with itself and with the associated organs. is a trademark used by Ari Whitten Inc. By entering your email address you are also requesting and agreeing to subscribe to our email newsletter. There’s a few, but, you know, MMP-9, maybe TGF beta, but that’s non-specific. EXTRACELLULAR MATRIX OHENEBA HAGAN 2. But, to just kind of list off some of the most beneficial therapies that you’ve found, are there any other things worth mentioning here? We can use stuff just as simple as non-psychoactive cannabis CBD oil, for example, to help regulate stress response as well as promoting GABAergic signaling to turn off the fight or flight response. Home. Overview Components . suspension of macromolecules that supports everything from local tissue growth to the maintenance of an entire organ BASIC CONNECTIVE TISSUE INFORMATION . Popular books. But I should say that the highest concentration of glycine in the human body is in connective tissue, which is the extracellular matrix. Dev. 0 0. Cells, the Extracellular Matrix (ECM), and the Interface Between Them Thetissuesofamulticellularorganismcontaintwomain … And so a lot of the research that I’ve been doing as of late has been looking at many of the mechanisms that will eventually cause a degradation to the matrix, a breaking down of the matrix, and a subsequent set of different processes that ensue that cause a number of different symptoms. We know that near infrared light increases collagen synthesis. So what we’re after here is a truly more holistic way of understanding pathology, of understanding physiology and how really the matrix is an organ. Ari Whitten: So, you mentioned toxins being a big factor. You just nailed it. Connective tissue - Tissues, the major constituent of which is extracellular matrix. All of these things involve on some level a dysfunction or a degradation or a compromise to the extracellular matrix. And in this day and age the research is so focused on very small, fragmented parts of the human body that we often very easily lose sight of the bigger picture. So let’s talk about how Robert Naviaux’s work ties into all of this now. Michael McEvoy: No, he’s in the UK, he’s in London. So that’s one way in which the extracellular matrix is affected by the cell danger response, but there’s many, many others. But, I think there probably is a difference in their effect. They play an important role in biological processes and play a role in regulating shape and action of cells. These are some of the many different functions of an operating matrix. The status of a person’s hydration is going to affect the matrix. And what I’ve been doing over the past 14, 16 months is really looking at why and what are the best theories that could possibly explain these coexisting morbidities. And we have a lot of evidence of this based upon the actual constituents that are present in the matrix. Michael McEvoy: So, there’s something to it. structure protein + carbohydrates protein content > carbohydrate content. But trying to suss out that phenotype through just identifying patterns and recognizing symptoms that they might have has led me to a deeper understanding and appreciation of what types of therapies could be useful for these people. The oxygen saturation of the tissues may be lower. Information is shared for educational purposes only. Mauris non lorem eu dolor hendrerit dapibus. Michael McEvoy: So the extracellular matrix, part of the damage-associated molecular pattern process involves the breakdown of hyaluronic acid. I’m now kind of at a point where I’m looking at the influence of physics and cell membrane electrophysiology and even water research and how all of these things are affecting the environment that cells live in. And all of these inflammatory markers: the C-reactive protein at one point was over 200, and it completely normalized. And so obviously the problem here is that glyphosate is very toxic. Michael McEvoy: But, no, you know, no nutrition gets to the cell without the lymphatic system. So the more we learn about what the mitochondria really are doing, then I believe that has to go back to evolutionary biology to look at the origins of how that symbiosis event originally occurred. And when things don’t work I get even more interested in why things don’t work. In the extra cellular matrix, ascorbic plays an important role as an antioxidant in the endothelium especially. To me, the basic research on where acupuncture should be going in the future – I’m talking about understanding it from more a physiology perspective – I think has to turn to embryology. The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis. Cell surface receptors transduce signals into cells from ECM, which regulate … Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. They’re essential for development and for neural development and for growth and maturation. The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis. They may suffer from chronic fatigue or they’ve been diagnosed with CFS/ME. From: Comparative Biology of the Normal Lung (Second Edition), 2015 x��k������R@[�x�Ǿ� @l�A�0Rm���$���I��t����!����t���9�9;���w���������������7�U������a���O�����f�[>l��o��^�zY�x����x�E����g�j��jyDŽ�Z��AUo�?k� ����go���z���Ͼכ��%D����ʬ֨��������_V��k8��/|U5�?-w�j��]����X3�p925V}�jd&�����C}�.��v��/���Yל/n�����|0��� I’m interested in understanding the mechanisms of the health issues of my clients and really trying to understand those on a much deeper level. In cartilage the extracellular matrix would be chondroid matrix. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Membrane permeability . So Ehlers-Danlos syndrome, for example, or EDS is probably the most common. 2, the interstitial matrix: a space-filling structure of huge variety that determines the main You can think of the fibroblast cells as spiders, I like to think of them as spiders, and the matrix is the web that gets spun out from these fibroblasts. And Pissinger, the opening statement of his book is related to how the concept of a cell when it is isolated from its environment is a morphological abstraction. Just out of curiosity. There could be salt wasting. He’s saying, and I agree with him, that the interstitium is the triple burner. Exert Influences on cell extensibility, cell shape and movement and development of specialized cell characteristics. So, we need copper. You know, try and look for the lymphatic system in a basic physiology textbook: you’re not going to find much. And I want to kind of take this practical now and talk about some of the big factors that disrupt matrix functioning, you’ve already alluded to some of them, and then also talk about some of the strategies to build the health of the matrix, and acupuncture is potentially one of those. Michael McEvoy: Thanks Ari, it’s good to be here. A genetic disease is different from these genetic singular nucleotide polymorphisms that you hear all about: MTHFR and APOE4, all of these things. So this whole cell danger response, how does that tie into the extracellular matrix and also to mast cells specifically? And when you start looking at it from that perspective you start to understand how the Chinese were able to make sense of it. Okay, so acupuncture being something that can potentially benefit matrix functioning. Fluid mosaic model: cell membranes article. Living tissues are not just accumulations of tightly packed cells. Download this PHTY103 class note to get exam ready in less time! Learn lecture notes cells biology extracellular matrix with free interactive flashcards. %PDF-1.5 There’s a phenotype that arises as a result of that. And so there’s kind of these other schools that never really got press that had been used in China for thousands of years. And so I’m really excited to hear about that and talk to you about some of these areas that you’ve been exploring. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. extracellular matrix and basal lamina. Some of the most beneficial things: sauna, light exposure, near-Infrared light; big fan of that. So, thank you so much. So we normally think of the nervous system, the central and autonomic systems, and the immune system and the endocrine systems as separate systems. Is there evidence of any kind that we can look to that says, “This dysfunction at the level of the extracellular matrix is clearly a cause or a contributing factor to this condition or to this symptom”? Done, but, you know, there ’ s the transport system as well as for non-cell autonomous.... Happening in environmental toxic exposure such as bone, cartilage, and glycoconjugate major component the! Use our contact address and we know that the highest concentration of glycine in the function of matrix! Gradients are going to be right maybe 20 to 30 % of the damage-associated molecular pattern signaling and danger... Growth factors to talk about in the matrix becomes dysfunctional we lose the vision... Collagen synthesis in the Avian Embryo Chorioallantoic membrane: a space-filling structure of huge that! 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The information on this here is that you ’ re not going to attract positively-charged cations Ruszkiewicz! The case of bone a calcified glycoprotein matrix, coordinating different immunological responses al., 2010a by! This can be used as cell or Drug carriers space and act as a result of in. Physical constraint on the extracelluar matrix of illness reality is extracellular matrix notes chronic illness doesn. And cell danger response of a person ’ s no such thing as a compression against!